Details

Autor(en) / Beteiligte

• Galván, Ana Belén
• Mallo, Mar
• Arenillas, Leonor
• Salido, Marta
• Espinet, Blanca
• Pedro, Carmen
• Florensa, Lourdes
• Serrano, Sergi
• Solé, Francesc

Titel

Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?

Ist Teil von

• Leukemia research, 2010-09, Vol.34 (9), p.1242-1245

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2010

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification.