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Antityrosinase and antimicrobial activities of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid
Ist Teil von
Food chemistry, 2011, Vol.124 (1), p.298-302
Ort / Verlag
Elsevier Ltd
Erscheinungsjahr
2011
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
The inhibition kinetics of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid on the enzyme activity of mushroom tyrosinase have been investigated. The results showed that these aromatic compounds can lead to reversible inhibition of the enzyme; furthermore, 2-phenylacetaldehyde and 2-phenylacetic acid are uncompetitive inhibitors and 2-phenylethanol is a mixed-type inhibitor. The inhibition constants have been determined and the inhibiting ability was: 2-phenylacetaldehyde
>
2-phenylacetic acid
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2-phenylethanol, indicating that the functional group on the benzene ring group played an important role in the inhibition of the enzyme. In addition, 2-phenylacetic acid and 2-phenylethanol were found to have effective antibacterial activities, and 2-phenylacetic acid was more effective against
Escherichia coli and
Ralstonia solanacearum than 2-phenylethanol, but 2-phenylacetaldehyde lacked of antibacterial activity.