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Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma
Journal of surgical oncology, 2008-05, Vol.97 (6), p.544-550
Lin, Chiao-Ying
Jeng, Yung-Ming
Chou, Han-Yi
Hsu, Hey-Chi
Yuan, Ray-Hwang
Chiang, Chun-Pin
Kuo, Mark Yen-Ping
2008
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Lin, Chiao-Ying
Jeng, Yung-Ming
Chou, Han-Yi
Hsu, Hey-Chi
Yuan, Ray-Hwang
Chiang, Chun-Pin
Kuo, Mark Yen-Ping
Titel
Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma
Ist Teil von
Journal of surgical oncology, 2008-05, Vol.97 (6), p.544-550
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2008
Quelle
MEDLINE
Beschreibungen/Notizen
Background and Objectives To investigate whether annexin A1 (ANXA1) expression is a marker in predicting the prognosis of oral cancer patients. Methods We immunohistochemically examined the expression of ANXA1 in 66 cases of oral epithelial dysplasia (OED) and 115 cases of oral squamous cell carcinoma (OSCC). The results were correlated with the clinicopathological parameters of tumors and overall patient survival. Results In normal oral mucosa, ANXA1 staining was predominantly located on the cell membrane. In OED and OSCC specimens, membranous staining decreased, whereas nuclear staining increased. Positive nuclear staining was observed in 9 of 66 (13.64%) OED cases and 63 of 115 (54.8%) OSCCs. Kaplan–Meier curves showed that OSCC patients with ANXA1 nuclear staining had significantly shorter overall lengths of survival (P = 0.00036 by the log‐rank test). Multivariate analysis showed that ANXA1 nuclear staining is a significant predictor of poor overall survival. And oral cancer SAS cells treated with hepatocyte growth factor (HGF) can induce ANXA1 protein translocation from cytoplasm to nucleus. Cells pretreated with LY294002 (PI3K inhibitor) almost completely inhibited (88.3% inhibition) HGF‐mediated ANXA1 nuclear translocation. Conclusions The nuclear localization of ANXA1 protein is a frequent event and could be used as a prognostic factor in OSCC. J. Surg. Oncol. 2008;97:544–550. © 2008 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0022-4790
eISSN: 1096-9098
DOI: 10.1002/jso.20992
Titel-ID: cdi_proquest_miscellaneous_754879031
Format
–
Schlagworte
annexin A1
,
Annexin A1 - metabolism
,
Biomarkers, Tumor
,
Carcinoma, Squamous Cell - metabolism
,
Carcinoma, Squamous Cell - pathology
,
Cell Membrane - metabolism
,
Cell Nucleus - metabolism
,
Chromones - pharmacology
,
Cytoplasm - metabolism
,
Cytoplasm - pathology
,
Enzyme Inhibitors - pharmacology
,
Epithelium - metabolism
,
Epithelium - pathology
,
Female
,
Fluorescent Antibody Technique
,
Hepatocyte Growth Factor - pharmacology
,
Humans
,
Immunoenzyme Techniques
,
Male
,
Middle Aged
,
Morpholines - pharmacology
,
Mouth Mucosa - metabolism
,
Mouth Mucosa - pathology
,
Mouth Neoplasms - metabolism
,
Mouth Neoplasms - pathology
,
Neoplasm Staging
,
oral squamous cell carcinoma
,
Phosphatidylinositol 3-Kinases - antagonists & inhibitors
,
Prognosis
,
Protein Transport
,
Subcellular Fractions
,
Survival Rate
,
Taiwan
,
Tumor Cells, Cultured
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