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Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non-small cell lung cancer patients
Molecular carcinogenesis, 2009-07, Vol.48 (7), p.633-641
Gao, Weimin
Mady, Hussam H.
Melhem, Mona F.
Keohavong, Phouthone
2009
Details
Autor(en) / Beteiligte
Gao, Weimin
Mady, Hussam H.
Melhem, Mona F.
Keohavong, Phouthone
Titel
Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non-small cell lung cancer patients
Ist Teil von
Molecular carcinogenesis, 2009-07, Vol.48 (7), p.633-641
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Our previous study showed a characteristic p53 mutational spectrum in lung tumors from lung cancer patients in the Western Pennsylvania region. To further understand the involvement of p53 mutations in lung tumor development, in this study we compared p53 mutational spectra and distribution between tumor cells taken from lung tumor tissue and histologically normal cells taken from tumor‐surrounding tissue obtained from 122 lung cancer patients [67 adenocarcinomas (ACs) and 55 squamous cell carcinomas (SCCs)]. Overall, mutations were detected in exons 5–8 of the p53 gene in cell samples from 39.3% (48/122) of the patients. Twenty‐four mutations were found among the ACs (35.8%, 24/67) and consisted mostly of G to T transversions at codon 248 in either only the tumor tissue (12 cases, 50%), or only the histologically normal tissue (2 cases, 8.3%), or both tissue types (10 cases, 41.7%). Among the SCCs, 24 mutations of both transition and transversion types were detected at multiple codons in either only the tumor tissue (17 cases, 70.8%), or only the histologically normal tissue (3 cases, 12.5%), or both tissues (4 cases, 16.7%). Overall, the distribution of mutations among the tumor tissue and histologically normal tissue was not significantly different between the ACs and SCCs (P > 0.05). In both groups, the mutations in the histologically normal tissue may be identical to or different from those in the tumor tissue. Therefore, p53 mutations are frequent in tumor‐surrounding histologically normal tissue, and some of them might be involved in lung carcinogenesis. © 2008 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0899-1987
eISSN: 1098-2744
DOI: 10.1002/mc.20505
Titel-ID: cdi_proquest_miscellaneous_754877801
Format
–
Schlagworte
Adenocarcinoma
,
Aged
,
Aged, 80 and over
,
Carcinogenesis
,
Carcinoma, Non-Small-Cell Lung - genetics
,
Codons
,
Exons
,
Female
,
Genes, p53
,
Humans
,
laser capture microdissection
,
Lung - metabolism
,
Lung cancer
,
lung carcinoma
,
Lung Neoplasms - genetics
,
Male
,
Middle Aged
,
Mutation
,
Non-small cell lung carcinoma
,
normal tissue
,
p53 mutation
,
p53 protein
,
smokers
,
squamous cell carcinoma
,
Transversion
,
Tumor cells
,
Tumors
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