Vaccine, 2010-06, Vol.28 (27), p.4356-4361
2010
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- Autor(en) / Beteiligte
- Titel
- Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: Waning of infancy-induced immune memory?
- Ist Teil von
- Vaccine, 2010-06, Vol.28 (27), p.4356-4361
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract To define the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity, anti-tetanus antibodies were assessed before and after boosting 162 adolescents and 219 children from Mfou (Cameroon). Among 63 adolescents with 3 recorded dose of infant DTP, 29/63 (46%) responded with a ≥4-fold increase of antibody titers, 35/63 (55%) reaching the 0.10 UI/ml threshold. Response rates were slightly higher (62%) in children aged 10–11 years. Responders and non-responders only differed significantly in their baseline anti-tetanus antibodies. Thus, early life immune immaturity may limit the persistence of infant-induced immunity and subsequent boosters may be required for sustained protection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2010.04.060Titel-ID: cdi_proquest_miscellaneous_754869693
- Format
- –
- Schlagworte
- Adolescent, Adolescents, Allergy and Immunology, Antibodies, Bacterial - immunology, Applied microbiology, Biological and medical sciences, Charitable foundations, Child, Confidence intervals, Female, Fundamental and applied biological sciences. Psychology, Health facilities, Humans, Immune memory, Immunization, Immunization, Secondary, Infancy, Infant, Infants, Male, Microbiology, Schools, Students, Tetanus, Tetanus toxoid, Tetanus Toxoid - administration & dosage, Tetanus Toxoid - immunology, Tropical diseases, Vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)