Cancer letters, 2010-08, Vol.294 (2), p.245-253
2010
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- Autor(en) / Beteiligte
- Titel
- A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro
- Ist Teil von
- Cancer letters, 2010-08, Vol.294 (2), p.245-253
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell proliferation through the induction of apoptosis. Next, we investigated the effects of zoledronic acid (ZOL) on MM cells, and found that ZOL also induced apoptosis in MM cells. Furthermore, ZOL augmented the inhibitory effects of the PLK-1 siRNA. In conclusion, combining a PLK-1 siRNA with ZOL treatment is an attractive strategy against MM.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2010.02.008Titel-ID: cdi_proquest_miscellaneous_754869271
- Format
- –
- Schlagworte
- Animals, Apoptosis, Apoptosis - drug effects, Apoptosis - genetics, Bisphosphonate, Cancer, Cancer therapies, Cell cycle, Cell Cycle Proteins - antagonists & inhibitors, Cell Cycle Proteins - biosynthesis, Cell Cycle Proteins - genetics, Cell division, Cell growth, Cell Growth Processes - drug effects, Cell Growth Processes - genetics, Cell Line, Tumor, Chimera - genetics, Combined Modality Therapy, Cytotoxicity, Deoxyribonucleic acid, Diphosphonates - pharmacology, DNA, DNA - blood, DNA - genetics, DNA-chimeric siRNA, Enzyme kinetics, Genetic Therapy - methods, Hematology, Oncology and Palliative Medicine, Humans, Imidazoles - pharmacology, Kinases, Malignant mesothelioma, Mesothelioma - enzymology, Mesothelioma - genetics, Mesothelioma - pathology, Mesothelioma - therapy, PLK-1, Polo-Like Kinase 1, Protein Serine-Threonine Kinases - antagonists & inhibitors, Protein Serine-Threonine Kinases - biosynthesis, Protein Serine-Threonine Kinases - genetics, Proteins, Proto-Oncogene Proteins - antagonists & inhibitors, Proto-Oncogene Proteins - biosynthesis, Proto-Oncogene Proteins - genetics, RNA interference, RNA, Small Interfering - administration & dosage, RNA, Small Interfering - blood, RNA, Small Interfering - genetics, Studies, Transfection, Zoledronic Acid