Journal of internal medicine, 2010-01, Vol.267 (1), p.54-70
2010
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Cell sheet engineering: a unique nanotechnology for scaffold‐free tissue reconstruction with clinical applications in regenerative medicine
- Ist Teil von
- Journal of internal medicine, 2010-01, Vol.267 (1), p.54-70
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2010
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- . Cell sheet technology (CST) is based on the use of thermoresponsive polymers, poly(N‐isopropylacrylamide) (PIPAAm). The surface of PIPAAms is formulated in such a way as to make its typical thickness <100 nm. In this review, we first focus on how the methods of PIPAAm‐grafted surface preparations and functionalization are important to be able to harvest a functional cell sheet, to be further transplanted. Then, we present aspects of tissue mimics and three‐dimensional reconstruction of a tissue in vitro. Finally, we give an overview of clinical applications and clinically relevant animal experimentations of the technology, such as cardiomyopathy, visual acuity, periodonty, oesophageal ulcerations and type 1 diabetes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0954-6820eISSN: 1365-2796DOI: 10.1111/j.1365-2796.2009.02185.xTitel-ID: cdi_proquest_miscellaneous_754867215
- Format
- –
- Schlagworte
- Animals, Biocompatible Materials, Biological and medical sciences, Cardiomyopathies - therapy, Cell Adhesion, Cell Culture Techniques - methods, cell sheet technology, Cells, Cultured, clinical applications, Corneal Diseases - therapy, Diabetes Mellitus, Type 1 - therapy, Esophageal Diseases - therapy, General aspects, Humans, Medical sciences, Membranes, Artificial, Nanotechnology, Rats, regenerative medicine, Regenerative Medicine - methods, scaffold‐free, Surface Properties, thermoresponsive polymer, Tissue Engineering - methods