Letters in applied microbiology, 2010-08, Vol.51 (2), p.177-183
2010
Details
- Autor(en) / Beteiligte
- Titel
- Use of chemosensitization to overcome fludioxonil resistance in Penicillium expansum
- Ist Teil von
- Letters in applied microbiology, 2010-08, Vol.51 (2), p.177-183
- Ort / Verlag
- Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To overcome fludioxonil resistance of Penicillium expansum, a mycotoxigenic fungal pathogen causing postharvest decay in apple, by using natural phenolic chemosensitizing agents. Fludioxonil-resistant mutants of P. expansum were co-treated with different oxidising and natural phenolic agents. Resistance was overcome by natural phenolic chemosensitizing agents targeting the oxidative stress-response pathway. These agents also augmented effectiveness of the fungicide, kresoxim-methyl. Results indicated that alkyl gallates target mitochondrial respiration and/or its antioxidation system. Fungal mitochondrial superoxide dismutase (Mn-SOD) plays a protective role against alkyl gallates. Natural chemosensitizing agents targeting the oxidative stress-response system, such as Mn-SOD, can synergize commercial fungicides. Redox-active compounds can serve as potent chemosensitizing agents to overcome resistance and lower effective dosages of fungicides. This can reduce costs with coincidental lowering of environmental and health risks.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0266-8254eISSN: 1472-765XDOI: 10.1111/j.1472-765X.2010.02875.xTitel-ID: cdi_proquest_miscellaneous_754559416
- Format
- –
- Schlagworte
- alkyl gallates, Antifungal Agents - pharmacology, antifungal properties, Biological and medical sciences, Dioxoles - pharmacology, Drug Interactions, Drug Resistance, Fungal - drug effects, enzyme activity, filamentous fungi, fludioxonil, Fundamental and applied biological sciences. Psychology, Fungal Proteins - metabolism, fungicides, kresoxim-methyl, Malus, Malus - microbiology, MAPK signalling, Metabolic Networks and Pathways - drug effects, Methacrylates - pharmacology, Microbiology, Mitochondria - drug effects, Mitochondrial Proteins - metabolism, natural products, Oxidants - pharmacology, Oxidative Stress, patulin, Penicillium - drug effects, Penicillium - isolation & purification, Penicillium expansum, pesticide resistance, phenolic compounds, Phenols - pharmacology, Phenylacetates - pharmacology, Pyrroles - pharmacology, Strobilurins, superoxide dismutase, Superoxide Dismutase - metabolism