Details

Autor(en) / Beteiligte

• Strom, J.G.
• Jun, H.Won

Titel

Kinetics of hydrolysis of methenamine

Ist Teil von

• Journal of pharmaceutical sciences, 1980-11, Vol.69 (11), p.1261-1263

Ort / Verlag

Washington: Elsevier Inc

Erscheinungsjahr

1980

Quelle

MEDLINE

Beschreibungen/Notizen

• The kinetics of degradation of methenamine were studied in citrate-phosphate buffers between pH 2.0 and 7.4 at 37.5° GLC was used to monitor the rate of hydrolysis. The conversion of methenamine to formaldehyde was found to be pH dependent in the buffers of constant ionic strength, with the reaction half-life decreasing from 13.8hr at pH 5.8 to 1.6hr at pH 2.0. The kinetics of degradation also were measured at 47, 57, and 67°, and the reaction obeyed the Arrhenius relationship. At pH 2.0, the activation energy was calculated to be 23.5 kcal/mole; at pH 5.1, it was 12.0 kcal/mole.