Details

Autor(en) / Beteiligte

• Novak, Marta
• Molnar, Miklos Zsolt
• Szeifert, Lilla
• Kovacs, Agnes Zsofia
• Vamos, Eszter Panna
• Zoller, Rezso
• Keszei, Andras
• Mucsi, Istvan

Titel

Depressive symptoms and mortality in patients after kidney transplantation: a prospective prevalent cohort study

Ist Teil von

• Psychosomatic medicine, 2010-07, Vol.72 (6), p.527-534

Ort / Verlag

United States: Lippincott Williams & Wilkins Ovid Technologies

Erscheinungsjahr

2010

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• To analyze in a prospective cohort study if depressive symptoms are an independent predictor of mortality in kidney transplant recipients. Data from 840 transplanted patients followed at a single outpatient transplant center were analyzed. Sociodemographic parameters and clinical data were collected at enrollment (between August 2002 and February 2003). Participants completed the Center for Epidemiologic Studies-Depression (CES-D) scale. Depression was defined as CES-D score of > or = 18. Data on 5-year outcomes (death censored graft loss or mortality) were collected. The prevalence of depression was 22%. Mortality was higher (21% versus 13%; p = .004) in patients with versus without depression. In a multivariate Cox proportional hazard model, both the baseline CES-D score (hazard ratio(for each 1-point increase) = 1.02; 95% confidence interval, 1.00-1.04) and the presence of depression at baseline (hazard ratio(presence) = 1.66; 95% confidence interval, 1.12-2.47) were significantly associated with mortality. The baseline CES-D score also significantly predicted death censored graft loss (hazard ratio(for each 1-point increase) = 1.03; 95% confidence interval, 1.01-1.05). Depressive symptoms are an independent predictor of mortality in kidney transplanted patients.