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The New England journal of medicine, 2010-08, Vol.363 (7), p.689-691
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2010
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Molecular dissection in three models of sepsis implicates a signaling pathway in maintaining adhesion of endothelial cells to protect against vascular leak.
Sepsis, derived from the Greek verb
sepo
(meaning “I rot”), has been recognized for millennia and refers to the disseminated inflammatory response elicited by microbial infections. Despite its ancient etymology, sepsis remains a current challenge: it is increasing in frequency, expensive to treat, and lethal, with an associated rate of death as high as 70%.
1
Despite intensive research over decades, few new therapies have been developed, and the mainstay of treatment remains nonspecific supportive care. Indeed, sepsis has been described as the “graveyard” of pharmaceutical discovery
2
because most drugs that appeared promising on the basis of in vitro and animal . . .