Details

Autor(en) / Beteiligte

• Feng, Xin
• Cui, Hai-Lei
• Xu, Shi
• Wu, Li
• Chen, Ying-Chun

Titel

Organocatalytic Direct Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactam to α,β-Unsaturated Aldehydes and an Illustration to Scaffold Diversity Synthesis

Ist Teil von

• Chemistry : a European journal, 2010-09, Vol.16 (34), p.10309-10312

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Ideal for scaffold diversity synthesis: The first organocatalytic direct vinylogous Michael addition of N‐Boc α,β‐unsaturated γ‐butyrolactam to α,β‐unsaturated aldehydes has been developed. The products with multiple orthogonal sets of functionalities were transformed into diverse enantioenriched natural‐product‐like or drug‐like molecules with fused bi‐, tri‐, or polycyclic scaffolds (see scheme), which might have potential for biologically related studies.