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Pentobarbital Anesthesia Reduces Blood–Brain Glucose Transfer in the Rat
Ist Teil von
Journal of neurochemistry, 1980-12, Vol.35 (6), p.1382-1387
Ort / Verlag
Oxford, UK: Blackwell Publishing Ltd
Erscheinungsjahr
1980
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
: Pentobarbital anesthesia (40 mg kg–1) was accompanied by a 50% decrease of blood flow and a 40% decrease of unidirectional blood‐brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, Tmax, decreased from 409 to 235 μ mol 100 g–1 min–1 and the half‐saturation constant, Km, from 8.8 to 4.9 mm. At 8.3–8.7 mm‐glucose in arterial plasma, the transfer constant (clearance) for unidirectional blood‐brain transfer decreased from 0.195 ± 0.011 in awake rats to 0.132 ± 0.005 ml g–1 min–1 in anesthetized rats. Half of the decrease was due to less complete diffusion‐limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased Tmax.