Biochemical and biophysical research communications, 1980-01, Vol.95 (1), p.111-117
1980
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Details
- Autor(en) / Beteiligte
- Titel
- Altered surface glycoproteins in melanoma cell variants with reduced metastasizing capacity selected for resistance to wheat germ agglutinin
- Ist Teil von
- Biochemical and biophysical research communications, 1980-01, Vol.95 (1), p.111-117
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 1980
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Variants of B 16-F 1 mouse melanoma cells selected for resistance to wheat germ agglutinin (WGA) toxicity in vitro were found to have undergone a stable surface change correlated both to lectin resistance and reduced metastasizing potential. The surface alteration, as indicated by the increased electrophoretic mobilities of several lactoperoxidase-iodinated cell surface proteins in SDS-PAGE, was restricted to polypeptides able to interact with WGA. The availability of lectin-resistant melanoma cell variants having altered metastasizing behavior provides a promising approach to studies of the role of specific cell surface components in the metastasizing process.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-291XeISSN: 1090-2104DOI: 10.1016/0006-291X(80)90711-1Titel-ID: cdi_proquest_miscellaneous_75261789
- Format
- –
- Schlagworte
- Animals, Cells, Cultured, Glycoproteins - metabolism, Lectins, Melanoma - metabolism, Melanoma - pathology, Membrane Proteins - metabolism, Mice, Molecular Weight, Neoplasm Metastasis, Neoplasm Proteins - metabolism, Neoplasms, Experimental, plant biochemistry, plant physiology, Receptors, Drug - metabolism