Details

Autor(en) / Beteiligte

• PETERSEN, SCOTT R.
• SHELDON, GEORGE F.
• CARPENTER, GARY

Titel

Autoregulation of Erythropoiesis by 2,3 Diphosphoglycerate during Hyperalimentation

Ist Teil von

• The journal of trauma, 1980-09, Vol.20 (9), p.750-754

Ort / Verlag

United States: Williams & Wilkins

Erscheinungsjahr

1980

Quelle

MEDLINE

Beschreibungen/Notizen

• Protein depletion in rats is associated with hemoconcentration, diminution of red cell mass, and suppression of erythropoiesis. In a rat model, repletion with standard diets or total parenteral nutrition was associated with gain in body weight and regeneration of red cell mass. Hematocrit values did not reflect the degree of red cell mass diminution associated with protein depletion. Intravenous repletion of normal and protein-depleted rats, unlike oral refed cohorts, was associated with elevated 2,3 diphosphoglycerate (DPG) values and a ‘relative anemia.’ It is postulated that elevated red cell 2,3 DPG lowers the hypoxie stimulus for erythropoietin production by enhancing oxygen unloading to the tissues, thus partially compensating for the anemia associated with total parenteral nutrition.