Details

Autor(en) / Beteiligte

• Wright, William B
• Greenblatt, Eugene N
• Day, Ivana P
• Quinones, Nicanor Q
• Hardy, Robert A

Titel

Derivatives of 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine as central nervous system agents

Ist Teil von

• Journal of medicinal chemistry, 1980-04, Vol.23 (4), p.462-465

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

1980

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Four 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepines were prepared and evaluated as central nervous system agents. All were active psychotropic agents as determined by animal screening tests. The most interesting compound, 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine, showed dual activity as an antidepressant against tetrabenazine depression and as a neuroleptic as measured by protection vs. amphetamine lethality in grouped mice.