Journal of pharmaceutical sciences, 1980-04, Vol.69 (4), p.444-446
1980
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Details
- Autor(en) / Beteiligte
- Titel
- Application of High-Pressure Liquid Chromatography and Thermal Energy Analyzer to Analysis of Trinitroglycerin and Its Metabolites in Blood
- Ist Teil von
- Journal of pharmaceutical sciences, 1980-04, Vol.69 (4), p.444-446
- Ort / Verlag
- Washington: Elsevier Inc
- Erscheinungsjahr
- 1980
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- A highly selective and sensitive analytical procedure for the determination of trinitroglycerin and four metabolites in whole blood was developed. Trinitroglycerin and its metabolites were extracted from whole blood with ethyl acetate and analyzed by high-pressure liquid chromatography using the thermal energy analyzer detector. Linearity of response was observed over the 1–1000-ng range. The applicability of this method to the analysis of whole blood from dogs orally dosed with trinitroglycerin is described.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3549eISSN: 1520-6017DOI: 10.1002/jps.2600690421Titel-ID: cdi_proquest_miscellaneous_75107928
- Format
- –
- Schlagworte
- Animals, Chromatography, High Pressure Liquid - methods, Dogs, Female, High-pressure liquid chromatography-analysis of trinitroglycerin and metabolites in whole blood, Hot Temperature, Nitroglycerin - blood, Nitroglycerin - metabolism, Thermal energy analyzer-analysis of trinitroglycerin and metabolites in whole blood, Time Factors, Trinitroglycerin-high-pressure liquid chromatographic analysis of parent drug and metabolites in whole blood