Details

Autor(en) / Beteiligte

• Münzel, Martin
• Globisch, Daniel
• Brückl, Tobias
• Wagner, Mirko
• Welzmiller, Veronika
• Michalakis, Stylianos
• Müller, Markus
• Biel, Martin
• Carell, Thomas

Titel

Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

Ist Teil von

• Angewandte Chemie (International ed.), 2010-07, Vol.49 (31), p.5375-5377

Ort / Verlag

Weinheim: Wiley-VCH Verlag

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Mind over matter: LC‐MS has allowed the amount of the post‐replicatively formed DNA base 5‐hydroxymethylcytosine (see picture; left) to be quantified in brain tissue. The nucleoside is most abundant in areas that are associated with higher cognitive functions, and its content in mouse hippocampi seems to increase with age. The new method enables hydroxymethylcytosine to be quantified with unprecedented accuracy.