Journal of natural products (Washington, D.C.), 2010-08, Vol.73 (8), p.1422-1426
2010
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Neuroprotective Xanthone Glycosides from Swertia punicea
- Ist Teil von
- Journal of natural products (Washington, D.C.), 2010-08, Vol.73 (8), p.1422-1426
- Ort / Verlag
- Northbrook, IL: American Chemical Society and American Society of Pharmacognosy
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Two new dimeric xanthone O-glycosides, puniceasides A (1) and B (2), a new trimeric O-glycoside, puniceaside C (3), and two new trimeric C-glycosides, puniceasides D (4) and E (5), together with 12 known xanthones were isolated from the entire plant of Swertia punicea. The structures of 1−5 were determined by HRESIMS and NMR spectroscopic methods. Compounds 2, 6, and 7 exhibited potent neuroprotective activity against H2O2-induced PC12 cell damage.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0163-3864eISSN: 1520-6025DOI: 10.1021/np100008rTitel-ID: cdi_proquest_miscellaneous_749001663
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Drugs, Chinese Herbal - chemistry, Drugs, Chinese Herbal - isolation & purification, Drugs, Chinese Herbal - pharmacology, General pharmacology, Glycosides - chemistry, Glycosides - isolation & purification, Glycosides - pharmacology, Hydrogen Peroxide - pharmacology, Medical sciences, Molecular Structure, Neuropharmacology, Neuroprotective agent, Neuroprotective Agents - chemistry, Neuroprotective Agents - isolation & purification, Neuroprotective Agents - pharmacology, Nuclear Magnetic Resonance, Biomolecular, PC12 Cells, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, Rats, Swertia - chemistry, Xanthones - chemistry, Xanthones - isolation & purification, Xanthones - pharmacology