Details

Autor(en) / Beteiligte

• Kleyensteuber, Brian
• Ruterbusch, Victor
• Bennett, Jason
• Llewellyn, David
• Loeffler, George

Titel

Limbic encephalitis presenting with seizures, anterograde amnesia, and psychosis in a patient seven weeks status post immature ovarian teratoma removal

Ist Teil von

• Military medicine, 2010-08, Vol.175 (8), p.616-618

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2010

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• A paraneoplastic syndrome associated with anti-N-methyl-D-asparate (NMDA) receptors can initially present as a neurologic or psychiatric disturbance. Removal of the tumor is usually curative, and the syndrome is associated with the presence, rather than the history, of tumor. We present a case in which a 25-year-old, Hispanic woman presented with seizures, memory loss, and unusual behavioral changes. The woman had a teratoma removed 2 months earlier. Because of the time course, a paraneoplastic syndrome was initially considered unlikely. Brain imaging, electroencephalography (EEG) and neurologic work-up were negative. The patient was treated for a suspected somatoform disorder and psychosis. Based on the clinical picture, the working diagnosis was changed to delirium due to paraneoplastic limbic encephalitis. A course of intravenous immunoglobins (IVIg), and high dose steroids was administered. The patient's symptoms improved, and she was discharged home. After discharge, studies came back positive for antibodies against NR1/NR2 of the NMDA receptor.