Details

Autor(en) / Beteiligte

• Altorjay, Istvan
• Vitalis, Zsuzsanna
• Tornai, Istvan
• Palatka, Karoly
• Kacska, Sandor
• Farkas, Gyula
• Udvardy, Miklos
• Harsfalvi, Jolan
• Dinya, Tamas
• Orosz, Peter
• Lombay, Bela
• Par, Gabriella
• Par, Alajos
• Csak, Timea
• Osztovits, Janos
• Szalay, Ferenc
• Csepregi, Antal
• Lakatos, Peter Laszlo
• Papp, Maria

Titel

Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis

Ist Teil von

• Journal of hepatology, 2010-09, Vol.53 (3), p.484-491

Ort / Verlag

Kidlington: Elsevier B.V

Erscheinungsjahr

2010

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background & Aims Mannose-binding lectin (MBL) is a serum lectin synthesized by the liver and involved in innate host defense. MBL deficiency increases the risk of various infectious diseases mostly in immune-deficient conditions. Bacterial infections are a significant cause of morbidity and mortality in liver cirrhosis due to the relative immuncompromised state. Methods Sera of 929 patients with various chronic liver diseases [autoimmune liver diseases (ALD), 406; viral hepatitis C (HCV), 185; and liver cirrhosis (LC) with various etiologies, 338] and 296 healthy controls (HC) were assayed for MBL concentration. Furthermore, a follow-up, observational study was conducted to assess MBL level as a risk factor for clinically significant bacterial infections in cirrhotic patients. Results MBL level and the prevalence of absolute MBL deficiency (<100 ng/ml) was not significantly different between patients and controls (ALD: 14.5%, HCV: 11.9%, LC: 10.7%, HC: 15.6%). In cirrhotic patients, the risk for infection was significantly higher among MBL deficient subjects as compared to non-deficient ones (50.0% vs. 31.8%, p = 0.039). In a logistic regression analysis, MBL deficiency was an independent risk factor for infections (OR: 2.14 95% CI: 1.03–4.45, p = 0.04) after adjusting for Child–Pugh score, co-morbidities, gender, and age. In a Kaplan–Meier analysis, MBL deficiency was associated with a shorter time to develop the first infectious complication (median days: 579 vs. 944, pBreslow = 0.016, pLogRank = 0.027) and was identified as an independent predictor in a multivariate Cox-regression analysis ( p = 0.003, OR: 2.33, 95% CI: 1.34–4.03). Conclusions MBL deficiency is associated with a higher probability and shorter time of developing infections in liver cirrhosis, further supporting the impact of the MBL molecule on the host defense.