Details

Autor(en) / Beteiligte

• Wu, Yan
• Ye, Xi-Hong
• Guo, Pei-Pei
• Xu, San-Peng
• Wang, Jie
• Yuan, Shi-Ying
• Yao, Shang-Long
• Shang, You

Titel

Neuroprotective Effect of Lipoxin A4 Methyl Ester in a Rat Model of Permanent Focal Cerebral Ischemia

Ist Teil von

• Journal of molecular neuroscience, 2010-10, Vol.42 (2), p.226-234

Ort / Verlag

New York: Humana Press Inc

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Neuroprotective effect of lipoxin A 4 methyl ester (LXA 4 ME) was tested in a rat model of permanent middle cerebral artery occlusion. LXA 4 ME was administrated through intracerebroventricular injection immediately after middle cerebral artery was occluded. Administration of LXA 4 ME ameliorated neurological deficit, reduced infarct volume, attenuated histological damage, and decreased number of apoptotic neuron induced by ischemic insult. These neuroprotective effects of LXA 4 ME were associated with inhibition of neutrophil infiltration, lipid peroxidation, and astrocyte activation. In addition, LXA 4 ME also attenuated proinflammatory cytokines (TNF-α and IL-1β) production. These data suggest that LXA 4 ME protects neuron against permanent cerebral ischemia by inhibiting inflammatory responses.