Details

Autor(en) / Beteiligte

• Van Riet‐Fox, Margaret F. Der
• Retief, A. E.
• Van Niekerk, W. A.

Titel

Chromosome changes in 17 human neoplasms studied with banding

Ist Teil von

• Cancer, 1979-12, Vol.44 (6), p.2108-2119

Ort / Verlag

New York: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

1979

Quelle

MEDLINE

Beschreibungen/Notizen

• Chromosome abnormalities from 17 malignancies that were studied using direct preparations and G‐, Q‐, and C‐banding methods are presented and the findings assessed. The material used was from 6 primary cervical carcinomas, 5 primary and metastatic ovarian carcinomas and 6 other metastatic carcinomas. In general, chromosome 1 was found to be involved more frequently than the others in structural aberrations. These included short arm deletions—the most frequent marker over all the cases—long arm deletions, long arm duplications and various translocations including more complex rearrangements involving different breakpoints. Altogether ten common markers were identified among the cases, of which two were shared between two cervical carcinomas and two more, between a pair of ovarian carcinomas. The evidence in this report is in agreement with the finding of widespread involvement of chromosome 1 in malignancy, but with a particular preponderance in ovarian carcinoma.