Journal of ethnopharmacology, 2010-02, Vol.127 (2), p.508-514
2010
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- Autor(en) / Beteiligte
- Titel
- Qualea parviflora Mart.: An integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action
- Ist Teil von
- Journal of ethnopharmacology, 2010-02, Vol.127 (2), p.508-514
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2010
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Qualea parviflora Mart. is a medicinal species commonly found in the Brazilian Cerrado biome. Based on ethnopharmacological data, methanolic extract from Qualea parviflora (QP) bark was evaluated for its antiulcer, analgesic, anti-hemorrhagic, mutagenic and anti- Helicobacter pylori activities. The gastroprotective action of the extract was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated mutagenic effect (Ames assay), anti- Helicobacter pylori, anti-hemorrhagic action, analgesic and inflammatory effects (hot-plate test and carrageenin-induced hind paw edema) of methanolic extract from Qualea parviflora. QP (500 mg/kg, p.o.) was able to protect gastric mucosa against HCl/ethanol solution (77%), absolute ethanol (97%), and also against injurious effect of NSAID (36%). When QP was challenged with sulfhydryl depletor compound, the gastroprotective action of extract was abolished. QP treatment was able to maintain the GSH level and show a concentration-dependent inhibition effect on the lipid peroxidation. QP present anti- Helicobacter pylori effect (MIC = 75 μg/mL), anti-hemorrhagic and antidiarrheal action but not present analgesic or anti-inflammatory effect. methanolic extract from Qualea parviflora had gastroprotective effect related to the increase of gastric mucosa defensive factors such PGE 2 levels and maintain the basal gastric glutathione levels. The methanolic extract also showed anti- Helicobacter pylori activity, anti-hemorrhagic effect and antioxidant action, but absence of analgesic, mutagenic and toxic effects, a profile that adds safety to its use.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0378-8741eISSN: 1872-7573DOI: 10.1016/j.jep.2009.10.005Titel-ID: cdi_proquest_miscellaneous_746299588
- Format
- –
- Schlagworte
- analgesic effect, animal models, animal pathogenic bacteria, Animals, Anti- Helicobacter pylori, anti-ulcer activity, Anti-Ulcer Agents - isolation & purification, Anti-Ulcer Agents - pharmacology, Anti-Ulcer Agents - therapeutic use, antibacterial properties, Antidiarrheals - isolation & purification, Antidiarrheals - pharmacology, Antidiarrheals - therapeutic use, bark, Biological and medical sciences, diarrhea, dosage, dose response, ethnobotany, Female, Gastric Mucosa - drug effects, Gastric Mucosa - pathology, Gastric protection, General pharmacology, Glutathione, Helicobacter pylori, Helicobacter pylori - drug effects, Helicobacter pylori - physiology, hemorrhage, Hemostatics - isolation & purification, Hemostatics - pharmacology, Hemostatics - therapeutic use, inflammation, lipid peroxidation, Male, Medical sciences, medicinal plants, medicinal properties, Mice, mutagenesis, Mutagenicity Tests - methods, pain, PGE 2 level, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, plant extracts, Plant Extracts - isolation & purification, Plant Extracts - pharmacology, Plant Extracts - therapeutic use, Plants, Medicinal, protective effect, Qualea parviflora, Qualea parviflora Mart, Rats, Rats, Wistar, traditional medicine, Vochysiaceae