Vaccine, 2009-06, Vol.27 (27), p.3675-3680
2009
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- Autor(en) / Beteiligte
- Titel
- The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine
- Ist Teil von
- Vaccine, 2009-06, Vol.27 (27), p.3675-3680
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract We are developing a radiation attenuated Plasmodium falciparum sporozoite (PfSPZ) malaria vaccine. An important step was to determine the minimum dose of irradiation required to adequately attenuate each sporozoite. This was studied in the Plasmodium yoelii rodent model system. Exposure to 100 Gy completely attenuated P. yoelii sporozoites (PySPZ). Next we demonstrated that immunization of mice intravenously with 3 doses of 750 PySPZ that had received 200 Gy, double the radiation dose required for attenuation, resulted in 100% protection. These results support the contention that a radiation attenuated sporozoite vaccine for malaria will be safe and effective at a range of radiation doses.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2008.11.073Titel-ID: cdi_proquest_miscellaneous_746229354
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Applied microbiology, Attenuation, Biological and medical sciences, Dose-Response Relationship, Radiation, Female, Fundamental and applied biological sciences. Psychology, Human protozoal diseases, Immunization, Infectious diseases, Life cycle. Host-agent relationship. Pathogenesis, Malaria, Malaria Vaccines - adverse effects, Malaria Vaccines - immunology, Malaria Vaccines - radiation effects, Medical sciences, Mice, Mice, Inbred BALB C, Mice, SCID, Microbiology, Parasitic diseases, Plasmodium falciparum, Plasmodium yoelii, Plasmodium yoelii - immunology, Protozoa, Protozoal diseases, Radiation, Safety, Sporozoites, Sporozoites - immunology, Sporozoites - radiation effects, Vaccine, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects), Vaccines, Attenuated - adverse effects, Vaccines, Attenuated - immunology, Vaccines, Attenuated - radiation effects