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Stathmin, a gene regulating neural plasticity, affects fear and anxiety processing in humans
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2010-01, Vol.153B (1), p.243-251
Brocke, Burkhard
Lesch, Klaus-Peter
Armbruster, Diana
Moser, Dirk A.
Müller, Anett
Strobel, Alexander
Kirschbaum, Clemens
2010
Details
Autor(en) / Beteiligte
Brocke, Burkhard
Lesch, Klaus-Peter
Armbruster, Diana
Moser, Dirk A.
Müller, Anett
Strobel, Alexander
Kirschbaum, Clemens
Titel
Stathmin, a gene regulating neural plasticity, affects fear and anxiety processing in humans
Ist Teil von
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2010-01, Vol.153B (1), p.243-251
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The identification of biological mechanisms underlying emotional behavior is crucial for our understanding of the pathogenesis of mental disorders. Besides genes modulating neural transmission and influencing amygdala reactivity and anxiety‐related temperamental traits a different plasticity regulating genes affect interindividual differences in emotional regulation. Recently it has been demonstrated that stathmin, a regulator of microtubule formation which affects long‐term potentiation (LTP), controls learned and innate fear responses in rodents, but its role in human emotion regulation is unknown. We hypothesized that in humans the gene coding for stathmin (STMN1), which is highly expressed in the lateral nucleus of the amygdala and associated thalamic and cortical structures, influences behavioral responses to fear and anxiety stimuli by way of two common single nucleotide polymorphisms (rs182455, SNP1; rs213641, SNP2). These polymorphisms are located within or close to the putative transcriptional control region. We used the acoustic startle paradigm and a standardized laboratory protocol for the induction of fear and psychosocial stress in 106 healthy volunteers to investigate the impact of stathmin gene variation on two fear‐ and anxiety‐controlling effector‐systems of the amygdala. We found that STMN1 genotype interacting with individuals' gender significantly impacts fear and anxiety responses as measured with the startle and cortisol stress response. We therefore conclude that STMN1 genotype has functional relevance for the acquisition and expression of basic fear and anxiety responses also in humans. © 2009 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4841
eISSN: 1552-485X
DOI: 10.1002/ajmg.b.30989
Titel-ID: cdi_proquest_miscellaneous_746153075
Format
–
Schlagworte
acoustic startle response
,
amygdala
,
anxiety
,
Anxiety - genetics
,
Biological and medical sciences
,
cortisol response
,
Fear
,
Female
,
Genetic Carrier Screening
,
Genotype
,
Haplotypes
,
Humans
,
Hydrocortisone - analysis
,
Long-Term Potentiation
,
Male
,
Medical genetics
,
Medical sciences
,
Neuronal Plasticity - genetics
,
Polymorphism, Single Nucleotide
,
Reflex, Startle
,
stathmin
,
Stathmin - genetics
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