UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 5 von 7
Datensatz exportieren als...
BibTeX
The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patients
Human psychopharmacology, 2009-06, Vol.24 (4), p.287-291
Szczepankiewicz, Aleksandra
Skibinska, Maria
Suwalska, Aleksandra
Hauser, Joanna
Rybakowski, Janusz K.
2009
Details
Autor(en) / Beteiligte
Szczepankiewicz, Aleksandra
Skibinska, Maria
Suwalska, Aleksandra
Hauser, Joanna
Rybakowski, Janusz K.
Titel
The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patients
Ist Teil von
Human psychopharmacology, 2009-06, Vol.24 (4), p.287-291
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2009
Link zum Volltext
Quelle
EBSCOhost Psychology and Behavioral Sciences Collection
Beschreibungen/Notizen
FYN belongs to the protein kinase family that phosphorylates NMDA receptor subunits, participating in the regulation of ion transmission and BDNF/TrkB signal transduction pathway. Lithium inhibits glutamatergic transmission via NMDA receptors, exerting neuroprotective effect against excitotoxicity. The aim of this study was to find possible association of three polymorphisms of FYN gene with prophylactic lithium response in the group of bipolar patients. We analyzed 101 bipolar patients treated with lithium carbonate for 5–27 years (mean 15 years). Twenty‐four patients were identified as excellent lithium responders (ER), 51 patients as partial responders (PRs), and 26 patients were non‐responders. Genotypes of the three analyzed polymorphisms were established by PCR‐RFLP. Statistical analysis was done with Statistica. No significant differences in genotype distribution and allele frequencies were observed between T/G and A/G FYN polymorphisms and lithium response. We observed a trend toward association of TT genotype and T allele of T/C polymorphism with worse lithium response. The results of the study demonstrated only marginal association between FYN polymorphisms and prophylactic lithium response in bipolar patients. The results are discussed in light of our previous studies on FYN gene in bipolar illness and BDNF gene in lithium response. Copyright © 2009 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0885-6222
eISSN: 1099-1077
DOI: 10.1002/hup.1018
Titel-ID: cdi_proquest_miscellaneous_746085144
Format
–
Schlagworte
Adult
,
Age of Onset
,
Aged
,
Alleles
,
Antimanic Agents - therapeutic use
,
association
,
bipolar disorder
,
Bipolar Disorder - genetics
,
Bipolar Disorder - prevention & control
,
Bipolar Disorder - psychology
,
Brain-Derived Neurotrophic Factor - metabolism
,
DNA - genetics
,
Female
,
FYN gene
,
Gene Frequency
,
Genotype
,
Humans
,
Lithium Carbonate - therapeutic use
,
lithium response
,
Male
,
Middle Aged
,
Neoplasm Proteins - metabolism
,
polymorphism
,
Polymorphism, Genetic - genetics
,
Polymorphism, Single Nucleotide
,
Protein-Tyrosine Kinases - metabolism
,
Proto-Oncogene Proteins c-fyn - genetics
,
Receptors, N-Methyl-D-Aspartate - physiology
,
Reverse Transcriptase Polymerase Chain Reaction
,
Treatment Outcome
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX