Details

Autor(en) / Beteiligte

• Dejnirattisai, Wanwisa
• Jumnainsong, Amonrat
• Onsirisakul, Naruthai
• Fitton, Patricia
• Vasanawathana, Sirijitt
• Limpitikul, Wannee
• Puttikhunt, Chunya
• Edwards, Carolyn
• Duangchinda, Thaneeya
• Supasa, Sunpetchuda
• Chawansuntati, Kriangkrai
• Malasit, Prida
• Mongkolsapaya, Juthathip
• Screaton, Gavin

Titel

Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans

Ist Teil von

• Science (American Association for the Advancement of Science), 2010-05, Vol.328 (5979), p.745-748

Ort / Verlag

Washington, DC: American Association for the Advancement of Science

Erscheinungsjahr

2010

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common. One hypothesis for the increased severity seen in secondary infections is antibody-dependent enhancement (ADE) leading to increased replication in Fc receptor-bearing cells. In this study, we have generated a panel of human monoclonal antibodies to dengue virus. Antibodies to the structural precursor-membrane protein (prM) form a major component of the response. These antibodies are highly cross-reactive among the dengue virus serotypes and, even at high concentrations, do not neutralize infection but potently promote ADE. We propose that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design.