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The role of postoperative radiotherapy for the treatment of gangliogliomas
Cancer, 2010-01, Vol.116 (2), p.432-442
Rades, Dirk
Zwick, Lena
Leppert, Jan
Bonsanto, Matteo M
Tronnier, Volker
Dunst, Juergen
Schild, Steven E.
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Rades, Dirk
Zwick, Lena
Leppert, Jan
Bonsanto, Matteo M
Tronnier, Volker
Dunst, Juergen
Schild, Steven E.
Titel
The role of postoperative radiotherapy for the treatment of gangliogliomas
Ist Teil von
Cancer, 2010-01, Vol.116 (2), p.432-442
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
BACKGROUND: Because of their rarity, no prospective studies have been performed regarding gangliogliomas. The optimal treatment regimen is unclear. In this study, the authors compared 4 therapies for local control (LC) and overall survival (OS) in patients with ganglioglioma. METHODS: In 402 patients with ganglioglioma, outcomes were compared for patients who underwent gross total resection alone (GTR) (n = 188), GTR plus radiotherapy (GTR + RT) (n = 21), subtotal resection alone (STR) (n = 113), and STR plus RT (STR + RT (n = 80). Age, sex, tumor site, and histologic grade also were investigated. Subgroup analyses were performed for both low‐grade and high‐grade tumors. RESULTS: The 10‐year LC rates were 89% after GTR, 90% after GTR + RT, 52% after STR, and 65% after STR + RT (P < .001); and the 10‐year OS rates were 95%, 95%, 62%, and 74%, respectively (P < .001). After STR, irradiation significantly improved LC (P = .004) but not OS (P = .22). After GTR, irradiation did not significantly improve LC (P = .23) or OS (P = .29). On multivariate analyses, LC and OS were associated with therapy and pathologic grade, and OS also was associated with tumor site. In low‐grade tumors, STR + RT resulted in better LC (P = .016) but not better OS (P = .18); and, after GTR, LC (P = .28) and OS (P = 1.0) were not improved with postoperative radiotherapy. In high‐grade tumors, STR + RT resulted in better LC (P = .016) but not better OS (P = .41); after GTR, LC (P = .56) and OS (P = .61) were not improved with irradiation. CONCLUSIONS: According to this review, GTR should be performed whenever safely possible and does not require postoperative irradiation. If only STR is achieved, then RT improves LC of both low‐grade and high‐grade tumors and, thus, should be considered seriously. Cancer 2010. © 2010 American Cancer Society. This study investigated the potential benefit of postoperative radiotherapy for local control (LC) and overall survival (OS) in a series of 402 patients with ganglioglioma. In both low‐grade and high‐grade tumors, irradiation significantly improved LC but not OS after subtotal resection and should be considered for these patients; whereas, after gross total resection, irradiation did not significantly improve LC or OS and, thus, did not appear to be required.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.24716
Titel-ID: cdi_proquest_miscellaneous_746050543
Format
–
Schlagworte
Adolescent
,
Adult
,
Biological and medical sciences
,
Brain Neoplasms - mortality
,
Brain Neoplasms - radiotherapy
,
Brain Neoplasms - surgery
,
Child
,
Child, Preschool
,
Combined Modality Therapy
,
Female
,
ganglioglioma
,
Ganglioglioma - mortality
,
Ganglioglioma - radiotherapy
,
Ganglioglioma - surgery
,
Humans
,
Infant
,
Infant, Newborn
,
local control
,
Male
,
Medical sciences
,
overall survival
,
Postoperative Period
,
postoperative radiotherapy
,
Radiotherapy, Adjuvant
,
resection
,
Retrospective Studies
,
Survival Analysis
,
Tumors
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