Details

Autor(en) / Beteiligte

• Berrie, Christopher P.
• Birdsall, Nigel J.M.
• Burgen, Arnold S.V.
• Hulme, Edward C.

Titel

Guanine nucleotides modulate muscarinic receptor binding in the heart

Ist Teil von

• Biochemical and biophysical research communications, 1979-04, Vol.87 (4), p.1000-1005

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1979

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The binding properties of muscarinic receptors in homogenates of the rat myocardium are altered in the presence of guanine nucleotides. There is a small increase in the affinity constant of the antagonist, [ 3H]-N-methylscopolamine, and a large decrease in agonist binding. The most potent nucleotide is Gpp(NH)p, with GTP and GDP both being about ten times less active. The effect of GTP on agonist binding is transient whereas that of Gpp(NH)p is more persistent.