Autonomic neuroscience, 2010-06, Vol.155 (1), p.98-103
2010
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- Autor(en) / Beteiligte
- Titel
- Lack of association between genetic polymorphisms affecting sympathetic activity and tilt-induced vasovagal syncope
- Ist Teil von
- Autonomic neuroscience, 2010-06, Vol.155 (1), p.98-103
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Although the pathophysiology of vasovagal syncope is not completely understood, the involvement of sympathetic nervous system alterations has been suggested. Since predisposition to fainting during orthostatic challenge may be associated with genetic variations, we sought to explore the role of genetic polymorphisms affecting sympathetic nervous system function in the susceptibility to tilt-induced vasovagal syncope. We genotyped 129 subjects with recurrent unexplained syncope who underwent tilt testing, and investigated the recurrence of syncope. The analysed polymorphisms were Arg492Cys ( ADRA1A gene), Ser49Gly and Arg389Gly ( ADRB1 ), Arg16Gly and Gln27Glu ( ADRB2 ), 825C/T ( GNB3 ), –1021C/T ( DBH ) and S/L ( SLC6A4 ). No association of the aforementioned genetic variants with both tilt test outcomes and new syncopal episodes during follow-up was found. None of the considered polymorphisms influencing sympathetic activity is a major risk factor for vasovagal syncope in Italian patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1566-0702eISSN: 1872-7484DOI: 10.1016/j.autneu.2010.01.002Titel-ID: cdi_proquest_miscellaneous_745937523
- Format
- –
- Schlagworte
- Adolescent, Adult, Advanced Basic Science, Aged, Biological and medical sciences, Female, Fundamental and applied biological sciences. Psychology, G-Protein-Coupled Receptor Kinase 3 - genetics, Genetic polymorphisms, Genetic Predisposition to Disease, Heterotrimeric GTP-Binding Proteins - genetics, Humans, Italian study, Male, Medical Education, Middle Aged, Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ, Polymorphism, Single Nucleotide, Posture, Receptors, Adrenergic, alpha-1 - genetics, Receptors, Adrenergic, beta-1 - genetics, Serotonin Plasma Membrane Transport Proteins - genetics, Sympathetic nervous system, Sympathetic Nervous System - physiology, Syncope, Vasovagal - genetics, Tilt table testing, Tilt-Table Test, Vasovagal syncope, Vertebrates: nervous system and sense organs, Young Adult