Details

Autor(en) / Beteiligte

• Park, Ji-Ae
• Kim, Hee-Kyung
• Kim, Joo-Hyun
• Jeong, Sang-Won
• Jung, Jae-Chang
• Lee, Gang-Ho
• Lee, Jongmin
• Chang, Yongmin
• Kim, Tae-Jeong

Titel

Gold nanoparticles functionalized by gadolinium–DTPA conjugate of cysteine as a multimodal bioimaging agent

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2287-2291

Ort / Verlag

Amsterdam: Elsevier Ltd

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• The work describes the synthesis and in vivo application of Au@GdL (L = DTPA-bis(amide) conjugate of cysteine) as a highly efficient MRI/CT multimodal contrast agent. The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14 nm with a loading of GdL reaching up to 2.9 × 10 3 per particles, and they demonstrate very high R1 relaxivity (∼10 5 mM −1 s −1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9 mM −1 s −1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent.