Science (American Association for the Advancement of Science), 2010-02, Vol.327 (5967), p.883-886
2010
Details
- Autor(en) / Beteiligte
- Titel
- Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection
- Ist Teil von
- Science (American Association for the Advancement of Science), 2010-02, Vol.327 (5967), p.883-886
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- Science Online_科学在线
- Beschreibungen/Notizen
- The human genome contains hundreds of regions whose patterns of genetic variation indicate recent positive natural selection, yet for most the underlying gene and the advantageous mutation remain unknown. We developed a method, composite of multiple signals (CMS), that combines tests for multiple signals of selection and increases resolution by up to 100-fold. By applying CMS to candidate regions from the International Haplotype Map, we localized population-specific selective signals to 55 kilobases (median), identifying known and novel causal variants. CMS can not just identify individual loci but implicates precise variants selected by evolution.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1183863Titel-ID: cdi_proquest_miscellaneous_745930351
- Format
- –
- Schlagworte
- Alleles, Biological and medical sciences, Biological evolution, Cellular biology, Computational Biology - methods, Datasets, DNA, Intergenic - genetics, Evolution, Evolution, Molecular, Evolutionary biology, Fundamental and applied biological sciences. Psychology, Genes, Genetic diversity, Genetic Loci, Genetic mutation, Genetic Variation, Genetics of eukaryotes. Biological and molecular evolution, Genome, Human, Genomes, Genomics, Haplotypes, Humans, Mutation, Polymorphism, Genetic, Population Groups - genetics, Positive selection, Regulatory Sequences, Nucleic Acid - genetics, Selection, Genetic, Signal transduction, Software