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A functional polymorphism in MMP1 could influence osteomyelitis development
Journal of bone and mineral research, 2010-04, Vol.25 (4), p.912-919
Montes, Angel Hugo
Valle‐Garay, Eulalia
Alvarez, Victoria
Pevida, Marta
García Pérez, Eva
Paz, Jose
Meana, Alvaro
Asensi, Victor
2010
Details
Autor(en) / Beteiligte
Montes, Angel Hugo
Valle‐Garay, Eulalia
Alvarez, Victoria
Pevida, Marta
García Pérez, Eva
Paz, Jose
Meana, Alvaro
Asensi, Victor
Titel
A functional polymorphism in MMP1 could influence osteomyelitis development
Ist Teil von
Journal of bone and mineral research, 2010-04, Vol.25 (4), p.912-919
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Osteomyelitis (OM) is a bone infection characterized by necrosis and new formation of bone. Because matrix metalloproteases (MMPs) play an important role in bone extracellular matrix remodeling, we investigated the role of some MMP polymorphisms in OM patients. A total of 118 OM patients and 300 blood donors were genotyped for the polymorphisms of MMP1 (−1607 1G/2G) and MMP13 (−77A/G). Levels of MMPs (−1, −2, −3, −8, ‐9, −10, and −13) and tissue inhibitors of metaloproteases (TIMP‐1, ‐2, and ‐4) in serum and in human osteoblasts obtained from OM biopsies also were determined. The MMP1 (–1607 2G/2G) genotype was significantly more frequent among OM patients compared with controls [65.3% versus 33.7%, χ2 = 26.85, odds ratio (OR) = 3.24, 95% confidence interval (CI) 2.03–5.2, p < .0001]. The MMP1 2G allele also was more frequent in OM patients (73.3% versus 57.2%, χ2 = 37.76, OR = 2.75, 95% CI 1.96–3.85, p < .0001). Carriers of the 2G allele had significantly higher osteoblast MMP1 mRNA and MMP‐1 serum levels than noncarriers (p < .04). Interleukin 1α (IL‐1α) increased MMP‐1 and ‐13 protein secretion and Ets1 mRNA expression by OM patients' osteoblasts. No association of the MMP13 (–77 A/G) polymorphism with OM was observed. The MMP1 (–1607 1G/2G) polymorphism might contribute to OM pathogenesis. This could be due to increased expression of MMP‐1 by osteoblasts and is regulated by IL‐1α. © 2010 American Society for Bone and Mineral Research
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1359/jbmr.091013
Titel-ID: cdi_proquest_miscellaneous_745928006
Format
–
Schlagworte
Adolescent
,
Adult
,
Aged
,
Aged, 80 and over
,
Biological and medical sciences
,
Child
,
cytokines
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Genetic Association Studies
,
Genetic Predisposition to Disease
,
Humans
,
Interleukin-1alpha - metabolism
,
Male
,
Matrix Metalloproteinase 1 - genetics
,
Matrix Metalloproteinase 10 - blood
,
Matrix Metalloproteinase 13 - blood
,
Matrix Metalloproteinase 13 - genetics
,
Matrix Metalloproteinase 2 - blood
,
Matrix Metalloproteinase 3 - blood
,
Matrix Metalloproteinase 8 - blood
,
Matrix Metalloproteinase 9 - blood
,
matrix proteins
,
Middle Aged
,
modeling and remodeling
,
osteoblasts
,
Osteoblasts - metabolism
,
Osteoblasts - pathology
,
Osteomyelitis - blood
,
Osteomyelitis - genetics
,
Polymorphism, Genetic
,
polymorphisms
,
Promoter Regions, Genetic
,
Proto-Oncogene Protein c-ets-1 - analysis
,
Skeleton and joints
,
Tissue Inhibitor of Metalloproteinases
,
Vertebrates: osteoarticular system, musculoskeletal system
,
Young Adult
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