Details

Autor(en) / Beteiligte

• Bartmann, W.
• Beck, G.
• Lerch, U.
• Teufel, H.
• Schölkens, B.

Titel

Luteolytic prostaglandins synthesis and biological activity

Ist Teil von

• Prostaglandins, 1979-02, Vol.17 (2), p.301-311

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1979

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Analogues of PGF 2α with enhanced luteolytic activity were synthesized using the Corey synthesis. The luteolytic activity of the new prostaglandins was tested in the hamster. In addition the smooth muscle activity of the new compounds was compared with that of PGA 2 on the longitudinal strip of rat stomach fundus. Structure-activity relationships in the new series of 17,18,19,20-tetranor-16-thienyl-oxy-PGF 2α are discussed.