Science (American Association for the Advancement of Science), 2003-05, Vol.300 (5622), p.1148-1151
2003
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Details
- Autor(en) / Beteiligte
- Titel
- Triggering the Interferon Antiviral Response through an IKK-Related Pathway
- Ist Teil von
- Science (American Association for the Advancement of Science), 2003-05, Vol.300 (5622), p.1148-1151
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2003
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IκB kinase (IKK)-related kinases IKKε and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1081315Titel-ID: cdi_proquest_miscellaneous_745638039
- Format
- –
- Schlagworte
- Antivirals, Biological and medical sciences, Cell Line, Cytokines, DNA-Binding Proteins - metabolism, Enzyme Activation, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Viral, Genetic transcription, HEK293 cells, Hepacivirus - immunology, Hepacivirus - physiology, Humans, I-kappa B Kinase, Immunologic adjuvants, Immunological adjuvants, Immunology, Infections, Interferon inducers, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Interferon Type I - biosynthesis, Interferon Type I - genetics, Interferons, Logical Thinking, Microbiology, Phosphorylation, Plasmids, Promoter Regions, Genetic, Protein-Serine-Threonine Kinases - metabolism, Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains, RNA, Small Interfering - metabolism, Transcription (Genetics), Transcription factors, Transcription Factors - metabolism, Transfection, Viral infections, Virology, Viruses