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Dendritic cells delivered inside human carcinomas are sequestered by interleukin‐8
International journal of cancer, 2005-08, Vol.116 (2), p.275-281
Feijoó, Esperanza
Alfaro, Carlos
Mazzolini, Guillermo
Serra, Patricia
Peñuelas, Iván
Arina, Ainhoa
Huarte, Eduardo
Tirapu, Iñigo
Palencia, Belén
Murillo, Oihana
Ruiz, Juan
Sangro, Bruno
Richter, José A.
Prieto, Jesús
Melero, Ignacio
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Feijoó, Esperanza
Alfaro, Carlos
Mazzolini, Guillermo
Serra, Patricia
Peñuelas, Iván
Arina, Ainhoa
Huarte, Eduardo
Tirapu, Iñigo
Palencia, Belén
Murillo, Oihana
Ruiz, Juan
Sangro, Bruno
Richter, José A.
Prieto, Jesús
Melero, Ignacio
Titel
Dendritic cells delivered inside human carcinomas are sequestered by interleukin‐8
Ist Teil von
International journal of cancer, 2005-08, Vol.116 (2), p.275-281
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Quelle
MEDLINE
Beschreibungen/Notizen
In the course of a clinical trial consisting of intratumoral injections of dendritic cells (DCs) transfected to produce interleukin‐12, the use of 111In‐labeled tracing doses of DCs showed that most DCs remained inside tumor tissue, instead of migrating out. In search for factors that could explain this retention, it was found that tumors from patients suffering hepatocellular carcinoma, colorectal or pancreatic cancer were producing IL‐8 and that this chemokine attracted monocyte‐derived dendritic cells that uniformly express both IL‐8 receptors CXCR1 and CXCR2. Accordingly, neutralizing antihuman IL‐8 monoclonal antibodies blocked the chemotactic attraction of DCs by recombinant IL‐8, as well as by the serum of the patients or culture supernatants of human colorectal carcinomas. In addition, tissue culture supernatants of colon carcinoma cells inhibited DC migration induced by MIP‐3β in an IL‐8‐dependent fashion. IL‐8 production in malignant tissue and the responsiveness of DCs to IL‐8 are a likely explanation of the clinical images, which suggest retention of DCs inside human malignant lesions. Impairment of DC migration toward lymphoid tissue could be involved in cancer immune evasion. © 2005 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.21046
Titel-ID: cdi_proquest_miscellaneous_745637190
Format
–
Schlagworte
Antibodies, Monoclonal
,
Antineoplastic agents
,
Biological and medical sciences
,
cancer
,
Cell Movement
,
Chemotaxis
,
Colonic Neoplasms - immunology
,
Colonic Neoplasms - therapy
,
dendritic cell
,
Dendritic Cells - immunology
,
Humans
,
IL‐8
,
Immunotherapy
,
Interleukin-12 - biosynthesis
,
Interleukin-8 - biosynthesis
,
Interleukin-8 - immunology
,
Liver Neoplasms - immunology
,
Liver Neoplasms - therapy
,
Medical sciences
,
Pancreatic Neoplasms - immunology
,
Pancreatic Neoplasms - therapy
,
Pharmacology. Drug treatments
,
Transfection
,
Tumors
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