Details

Autor(en) / Beteiligte

• Zhang, Yanxu
• Tao, Shu
• Shen, Huizhong
• Ma, Jianmin

Titel

Inhalation exposure to ambient polycyclic aromatic hydrocarbons and lung cancer risk of Chinese population

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (50), p.21063-21067

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• An Euler atmospheric transport model (Canadian Model for Environmental Transport of Organochlorine Pesticides, CanMETOP) was applied and validated to estimate polycyclic aromatic hydrocarbon (PAH) ambient air concentrations at ground level in China based on a high-resolution emission inventory. The results were used to evaluate lung cancer risk for the Chinese population caused by inhalation exposure to PAHs. The uncertainties of the transport model, exposure, and risk analysis were assessed by using Monte Carlo simulation, taking into consideration the variation in PAH emission, aerosol and OH radical concentrations, dry deposition, respiration rate, and genetic susceptibility. The average benzo[a]pyrene equivalent concentration (B[a]Peq) was 2.43 [[almost equal to]1.29-4.50 as interquartile range (IR)] ng/m³. The population-weighted B[a]Peq was 7.64 (IR, [almost equal to]4.05-14.1) ng/m³ because of the spatial overlap of the emissions and population density. It was estimated that 5.8% (IR, [almost equal to]2.0-11%) of China's land area, where 30% (IR, [almost equal to]17-43%) of the population lives, exceeded the national ambient B[a]Peq standard of 10 ng/m³. Taking into consideration the variation in exposure concentration, respiration rate, and susceptibility, the overall population attributable fraction (PAF) for lung cancer caused by inhalation exposure to PAHs was 1.6% (IR, [almost equal to]0.91-2.6%), corresponding to an excess annual lung cancer incidence rate of 0.65 x 10⁻⁵. Although the spatial variability was high, the lung cancer risk in eastern China was higher than in western China, and populations in major cities had a higher risk of lung cancer than rural areas. An extremely high PAF of >44% was estimated in isolated locations near small-scale coke oven operations.