Clinical microbiology and infection, 2010-02, Vol.16 (2), p.184-186
2010
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Intravenous fosfomycin for the treatment of nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: a prospective evaluation
- Ist Teil von
- Clinical microbiology and infection, 2010-02, Vol.16 (2), p.184-186
- Ort / Verlag
- Oxford, UK: Elsevier Ltd
- Erscheinungsjahr
- 2010
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- Intensive care unit (ICU)-acquired infections as a result of multidrug-resistant Gram-negative pathogens remain a serious problem in critically ill patients. Adult ICU patients who received intravenous fosfomycin were prospectively examined to assess its safety and effectiveness as an adjunct to the antimicrobial therapy of life-threatening infections caused by carbapenem-resistant Klebsiella pneumoniae. Fosfomycin was administered intravenously in 11 patients for treatment of hospital-acquired infections caused by carbapenem-resistant K. pneumoniae. Fosfomycin (2–4 g every 6 h) was administered in combination with other antibiotics. The mean ± SD duration of treatment was 14 ± 5.6 days. All patients had good bacteriological and clinical outcome of infection. All-cause hospital mortality was two out of 11 (18.2%) patients. No patient experienced adverse events related to the administration of fosfomycin. Intravenous fosfomycin may be a beneficial and safe adjunctive treatment in the management of life-threatening ICU-acquired infections caused by carbapenem-resistant K. pneumoniae.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1198-743XeISSN: 1469-0691DOI: 10.1111/j.1469-0691.2009.02921.xTitel-ID: cdi_proquest_miscellaneous_745609348
- Format
- –
- Schlagworte
- Aged, Aged, 80 and over, Anti-Bacterial Agents - administration & dosage, Anti-Bacterial Agents - adverse effects, Anti-Bacterial Agents - pharmacology, Anti-Bacterial Agents - therapeutic use, Antibacterial agents, Antibiotics, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antimicrobial agents, beta-Lactam Resistance, Biological and medical sciences, Carbapenem-resistant Klebsiella pneumoniae, Carbapenems - pharmacology, colistin, Critical Illness, Cross Infection - drug therapy, Cross Infection - microbiology, Drug resistance, Female, fosfomycin, Fosfomycin - administration & dosage, Fosfomycin - adverse effects, Fosfomycin - therapeutic use, General aspects, Hospitals, Human infectious diseases. Experimental studies and models, Humans, ICU-acquired infection, Infectious diseases, Infusions, Intravenous, Intensive Care Units, Intravenous administration, Klebsiella Infections - drug therapy, Klebsiella Infections - microbiology, Klebsiella pneumoniae, Klebsiella pneumoniae - drug effects, Klebsiella pneumoniae - isolation & purification, Male, Medical sciences, Middle Aged, Mortality, Nosocomial infection, Pathogens, Pharmacology. Drug treatments, Pneumology, Prospective Studies, Respiratory system : syndromes and miscellaneous diseases, Treatment Outcome, ventilator-associated pneumonia