Details

Autor(en) / Beteiligte

• Naldi, Luigi
• Chatenoud, Liliane
• Linder, Dennis
• Belloni Fortina, Anna
• Peserico, Andrea
• Virgili, Anna Rosa
• Bruni, Pier Luigi
• Ingordo, Vito
• Scocco, Giovanni Lo
• Solaroli, Carmen
• Schena, Donatella
• Barba, Annalisa
• Di Landro, Anna
• Pezzarossa, Enrico
• Arcangeli, Fabio
• Gianni, Claudia
• Betti, Roberto
• Carli, Paolo
• Farris, Alessandro
• Barabino, Gian Franco
• Vecchia, Carlo La

Titel

Cigarette Smoking, Body Mass Index, and Stressful Life Events as Risk Factors for Psoriasis: Results from an Italian Case–Control Study

Ist Teil von

• Journal of investigative dermatology, 2005-07, Vol.125 (1), p.61-67

Ort / Verlag

Danvers, MA: Elsevier Inc

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• We conducted a case–control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n=560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n=690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR=5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR=1.6 and 1.9 for over weighted, BMI 26–29, and obese, BMI ≥ 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values ≥115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.