Details

Autor(en) / Beteiligte

• Warnecke-Eberz, Ute
• Bollschweiler, Elfriede
• Drebber, Uta
• Metzger, Ralf
• Baldus, Stephan E
• Hölscher, Arnulf H
• Mönig, Stefan

Titel

Prognostic Impact of Protein Overexpression of the Proto-oncogene PIM-1 in Gastric Cancer

Ist Teil von

• Anticancer research, 2009-11, Vol.29 (11), p.4451-4455

Ort / Verlag

Greece: International Institute of Anticancer Research

Erscheinungsjahr

2009

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Background: PIM kinases are mediators of cytokine signalling pathways in hematopoietic cells and contribute to the progression of certain types of leukemia and solid tumor. Here the prognostic impact of proto-oncogene PIM-1 was analyzed in gastric carcinoma. Patients and Methods: Cancer tissues of 117 patients with potentially curative (R0) resections for gastric cancer were immunohistochemically stained for PIM-1. Results: Cytoplasmic immunoreactivity for PIM-1 in tumor (46%) was higher (p=0.003) compared to that in gastric glands (16%) and foveolae (1%). PIM-1 immunoreactivity in gastric carcinoma correlated with tumor grading (p<0.05) and Laurén category (p<0.02). Overexpression of PIM-1 in gastric glands (p<0.001) was associated with formation of lymph node metastases (p=0.035) and survival (p=0.04). Multivariate analysis of PIM-1 expression in gastric glands confirmed its association with prognosis. Conclusion: Up-regulation of PIM-1 oncogene might be a tumor marker for gastric cancer. The correlation of PIM-1 overexpression in gastric glands with formation of lymph node metastases and survival proposes a prognostic role in gastric cancer.