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Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma
Genes chromosomes & cancer, 2010-05, Vol.49 (5), p.439-451
Espinet, Blanca
Salaverria, Itziar
Beà, Sílvia
Ruiz-Xivillé, Neus
Balagué, Olga
Salido, Marta
Costa, Dolors
Carreras, Joaquim
Rodríguez-Vicente, Ana Eugenia
Luís García, Juan
Hernández-Rivas, Jesús María
Calasanz, María José
Siebert, Reiner
Ferrer, Ana
Salar, Antonio
Carrió, Ana
Polo, Natividad
García-Marco, José Antonio
Domingo, Alicia
González-Barca, Eva
Romagosa, Vicenç
Marugán, Isabel
López-Guillermo, Armando
Millá, Fuensanta
Luís Mate, José
Luño, Elisa
Sanzo, Carmen
Collado, Rosa
Oliver, Isabel
Monzó, Sebastià
Palacín, Antonio
González, Teresa
Sant, Francesc
Salinas, Ramon
Ardanaz, María Teresa
Font, Llorenç
Escoda, Lourdes
Florensa, Lourdes
Serrano, Sergi
Campo, Elias
Solé, Francesc
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Espinet, Blanca
Salaverria, Itziar
Beà, Sílvia
Ruiz-Xivillé, Neus
Balagué, Olga
Salido, Marta
Costa, Dolors
Carreras, Joaquim
Rodríguez-Vicente, Ana Eugenia
Luís García, Juan
Hernández-Rivas, Jesús María
Calasanz, María José
Siebert, Reiner
Ferrer, Ana
Salar, Antonio
Carrió, Ana
Polo, Natividad
García-Marco, José Antonio
Domingo, Alicia
González-Barca, Eva
Romagosa, Vicenç
Marugán, Isabel
López-Guillermo, Armando
Millá, Fuensanta
Luís Mate, José
Luño, Elisa
Sanzo, Carmen
Collado, Rosa
Oliver, Isabel
Monzó, Sebastià
Palacín, Antonio
González, Teresa
Sant, Francesc
Salinas, Ramon
Ardanaz, María Teresa
Font, Llorenç
Escoda, Lourdes
Florensa, Lourdes
Serrano, Sergi
Campo, Elias
Solé, Francesc
Titel
Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma
Ist Teil von
Genes chromosomes & cancer, 2010-05, Vol.49 (5), p.439-451
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Mantle cell lymphoma (MCL) is a mature B‐cell neoplasm with an aggressive behavior, characterized by the t(11;14)(q13;q32). Several secondary genetic abnormalities with a potential role in the oncogenic process have been described. Studies of large MCL series using conventional cytogenetics, and correlating with proliferation and survival, are scarce. We selected 145 MCL cases at diagnosis, displaying an aberrant karyotype, from centers belonging to the Spanish Cooperative Group for Hematological Cytogenetics. Histological subtype, proliferative index and survival data were ascertained. Combined cytogenetic and molecular analyses detected CCND1 translocations in all cases, mostly t(11;14)(q13;q32). Secondary aberrations were present in 58% of patients, the most frequent being deletions of 1p, 13q and 17p, 10p alterations and 3q gains. The most recurrent breakpoints were identified at 1p31‐32, 1p21‐22, 17p13, and 1p36. Aggressive blastoid/pleomorphic variants displayed a higher karyotypic complexity, a higher frequency of 1p and 17p deletions and 10p alterations, a higher proliferation index and poor survival. Gains of 3q and 13q and 17p13 losses were associated with reduced survival times. Interestingly, gains of 3q and 17p losses added prognostic significance to the morphology in a multivariate analysis. Our findings confirm previous observations indicating that proliferation index, morphology and several secondary genetic alterations (3q gains and 13q and 17p losses) have prognostic value in patients with MCL. Additionally, we observed that 3q gains and 17p losses detected by conventional cytogenetics are proliferation‐independent prognostic markers indicating poor outcome. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1045-2257
eISSN: 1098-2264
DOI: 10.1002/gcc.20754
Titel-ID: cdi_proquest_miscellaneous_744621908
Format
–
Schlagworte
Adult
,
Aged
,
Aged, 80 and over
,
Cell Growth Processes - genetics
,
Chi-Square Distribution
,
Chromosome Aberrations
,
Cohort Studies
,
Cyclin D1 - genetics
,
Cytogenetic Analysis
,
Female
,
Gene Rearrangement
,
Humans
,
Immunohistochemistry
,
Kaplan-Meier Estimate
,
Lymphoma, Mantle-Cell - diagnosis
,
Lymphoma, Mantle-Cell - genetics
,
Lymphoma, Mantle-Cell - pathology
,
Male
,
Middle Aged
,
Prognosis
,
Proportional Hazards Models
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