ChemMedChem, 2008-09, Vol.3 (9), p.1316-1321
2008
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- Autor(en) / Beteiligte
- Titel
- Rational Design and Synthesis of 2,2-Bisheterocycle Tandem Derivatives as Non-Nucleoside Hepatitis B Virus Inhibitors
- Ist Teil von
- ChemMedChem, 2008-09, Vol.3 (9), p.1316-1321
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2008
- Quelle
- Access via Wiley Online Library
- Beschreibungen/Notizen
- Non‐nucleoside tandem derivatives: Potent hepatitis B antiviral activity is established for 2,2′‐bisthiazole heterocyclic derivatives. The core structure of these compounds differs from those of known non‐nucleoside hepatitis B antiviral agents, constituting a new direction in hepatitis B virus drug development.
- Sprache
- Englisch; Deutsch
- Identifikatoren
- ISSN: 1860-7179eISSN: 1860-7187DOI: 10.1002/cmdc.200800136Titel-ID: cdi_proquest_miscellaneous_744615455
- Format
- –
- Schlagworte
- 2,2′‐bisheterocycle tandem, 2′-bisheterocycle tandem, antiviral agents, Antiviral Agents - chemical synthesis, Antiviral Agents - chemistry, Antiviral Agents - pharmacology, Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis, Bridged Bicyclo Compounds, Heterocyclic - chemistry, Bridged Bicyclo Compounds, Heterocyclic - pharmacology, Drug Design, Hepatitis B virus, Hepatitis B virus - drug effects, leucamide A, Microbial Sensitivity Tests, Molecular Structure, non-nucleoside inhibitors, Small Molecule Libraries, Stereoisomerism, Structure-Activity Relationship, Thiazoles - chemical synthesis, Thiazoles - chemistry, Thiazoles - pharmacology, Viral Nonstructural Proteins - drug effects, Virus Replication - drug effects