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Should heart, lung, and liver transplant recipients receive immunosuppression induction for kidney transplantation?
Clinical transplantation, 2010-01, Vol.24 (1), p.67-72
Ranney, D.N.
Englesbe, M.J.
Muhammad, W.
Al-Holou, S.N.
Park, J.M.
Pelletier, S.J.
Punch, J.D.
Lynch, R.J.
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ranney, D.N.
Englesbe, M.J.
Muhammad, W.
Al-Holou, S.N.
Park, J.M.
Pelletier, S.J.
Punch, J.D.
Lynch, R.J.
Titel
Should heart, lung, and liver transplant recipients receive immunosuppression induction for kidney transplantation?
Ist Teil von
Clinical transplantation, 2010-01, Vol.24 (1), p.67-72
Ort / Verlag
Oxford, UK: Blackwell Publishing Ltd
Erscheinungsjahr
2010
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
Ranney DN, Englesbe MJ, Muhammad W, Al‐Holou SN, Park JM, Pelletier SJ, Punch JD, Lynch RJ. Should heart, lung, and liver transplant recipients receive immunosuppression induction for kidney transplantation? Clin Transplant 2010: 24: 67–72. © 2009 John Wiley & Sons A/S. : As the outcomes of heart, liver, and lung transplantation continue to improve, more patients will present for subsequent renal transplantation. It remains unclear whether these patients benefit from induction immunosuppression. We retrospectively reviewed induction on solid organ graft recipients who underwent renal transplant at our center from January 1, 1995 to March 30, 2007. Induction and the non‐induction groups were compared by univariate and Kaplan–Meier analyses. There were 21 patients in each group, with mean follow‐up of 4.5–6.0 years. Forty‐seven percent of patients receiving induction had a severe post‐operative infection, compared with 28.6% in the non‐induction group (p = NS). The one yr rejection rate in the induction group was 9.5% compared with 14.3% for non‐induction (p = NS). One‐yr graft survival was 81.0% and 95.2% in the induction and non‐induction group (p = NS). In summary, there is a trend toward lower patient and graft survival among patients undergoing induction. These trends could relate to selection bias in the decision to prescribe induction immunosuppression, but further study is needed to better define the risks and benefits of antibody‐induction regimens in this population.
Sprache
Englisch
Identifikatoren
ISSN: 0902-0063
eISSN: 1399-0012
DOI: 10.1111/j.1399-0012.2009.00973.x
Titel-ID: cdi_proquest_miscellaneous_744584349
Format
–
Schlagworte
Adult
,
Biological and medical sciences
,
Cohort Studies
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Fundamental immunology
,
Graft Survival
,
Heart Diseases - complications
,
Heart Diseases - immunology
,
Heart Diseases - surgery
,
Humans
,
Immunosuppression - methods
,
Immunosuppressive Agents - administration & dosage
,
induction
,
Kidney Failure, Chronic - complications
,
Kidney Failure, Chronic - mortality
,
Kidney Failure, Chronic - surgery
,
Liver Diseases - complications
,
Liver Diseases - immunology
,
Liver Diseases - surgery
,
Lung Diseases - complications
,
Lung Diseases - immunology
,
Lung Diseases - surgery
,
Male
,
Medical sciences
,
Middle Aged
,
Organ Transplantation
,
renal transplant
,
Retrospective Studies
,
simulect sensitization
,
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
,
Surgery of the urinary system
,
Survival Analysis
,
thymoglobulin
,
Tissue, organ and graft immunology
,
transplant survival
,
Treatment Outcome
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