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Science (American Association for the Advancement of Science), 2000-06, Vol.288 (5474), p.2219-2222

2000

Autor(en) / Beteiligte

Titel

Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation

Ist Teil von

Science (American Association for the Advancement of Science), 2000-06, Vol.288 (5474), p.2219-2222

Ort / Verlag

Washington, DC: American Society for the Advancement of Science

Erscheinungsjahr

2000

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

T helper 1 (TH1) cells mediate cellular immunity, whereas TH2 cells potentiate antiparasite and humoral immunity. We used a complementary DNA subtraction method, representational display analysis, to show that the small guanosine triphosphatase Rac2 is expressed selectively in murine TH1 cells. Rac induces the interferon-γ (IFN-γ) promoter through cooperative activation of the nuclear factor kappa B and p38 mitogen-activated protein kinase pathways. Tetracycline-regulated transgenic mice expressing constitutively active Rac2 in T cells exhibited enhanced IFN-γ production. Dominant-negative Rac inhibited IFN-γ production in murine T cells. Moreover, T cells from Rac2-/-mice showed decreased IFN-γ production under TH1 conditions in vitro. Thus, Rac2 activates TH1-specific signaling and IFN-γ gene expression.

Sprache: Englisch
Identifikatoren: ISSN: 0036-8075
eISSN: 1095-9203
DOI: 10.1126/science.288.5474.2219
Titel-ID: cdi_proquest_miscellaneous_743736573

Format: –
Schlagworte: Animals, Biological and medical sciences, Cell Differentiation, Cells, Cells, Cultured, Cellular differentiation, Commensals, Complementary DNA, Cultured cells, Cytokines, Cytokines - biosynthesis, Cytokines - genetics, Fundamental and applied biological sciences. Psychology, Fundamental immunology, g-Interferon, Gene Expression Regulation, Humans, Immunobiology, Immunology, Individualized Instruction, Interferon-gamma - biosynthesis, Interferon-gamma - genetics, JNK Mitogen-Activated Protein Kinases, Jurkat Cells, Logical Thinking, Lymphocyte Activation, Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation, Mice, Mice, Transgenic, Mitogen-Activated Protein Kinases - metabolism, NF-kappa B - metabolism, p38 Mitogen-Activated Protein Kinases, Plasmids, Promoter Regions, Genetic, Proteins, rac GTP-Binding Proteins - genetics, rac GTP-Binding Proteins - metabolism, RAC2 GTP-Binding Protein, Rac2 protein, Rodents, Signal Transduction, Subtraction, T lymphocytes, Th1 Cells - cytology, Th1 Cells - immunology, Th1 Cells - metabolism, Transfection, Transgenes, Transgenic animals

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