Science (American Association for the Advancement of Science), 1998-09, Vol.281 (5384), p.1857-1859
1998
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Details
- Autor(en) / Beteiligte
- Titel
- Fertilization Defects in Sperm from Mice Lacking Fertilin β
- Ist Teil von
- Science (American Association for the Advancement of Science), 1998-09, Vol.281 (5384), p.1857-1859
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1998
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin β were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in spermzona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.281.5384.1857Titel-ID: cdi_proquest_miscellaneous_743670872
- Format
- –
- Schlagworte
- ADAM Proteins, Adhesion, Animals, Biological and medical sciences, Calcium - metabolism, Cell Adhesion, Cell Membrane - physiology, Cell membranes, Cellular biology, Classical genetics, quantitative genetics, hybrids, Exons, Fallopian Tubes, Female, Female animals, Females, Fertilins, Fertilization (Biology), Fundamental and applied biological sciences. Psychology, Genetics of eukaryotes. Biological and molecular evolution, Male, Male animals, Males, Mating behavior, Membrane Fusion, Membrane Glycoproteins - genetics, Membrane Glycoproteins - metabolism, Membrane Glycoproteins - physiology, Membranes, Metalloendopeptidases - genetics, Metalloendopeptidases - metabolism, Metalloendopeptidases - physiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular biology, Ova, Oviducts, Ovum - physiology, Plasma, Polymerase chain reaction, Proteins, Reproductive system, Rodents, Sperm Capacitation, Sperm-Ovum Interactions, Spermatogenesis, Spermatozoa, Spermatozoa - chemistry, Spermatozoa - physiology, Vertebrata, Zona Pellucida - physiology