Science (American Association for the Advancement of Science), 1999-05, Vol.284 (5418), p.1362-1365
1999
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Details
- Autor(en) / Beteiligte
- Titel
- Identification of a Nuclear Receptor for Bile Acids
- Ist Teil von
- Science (American Association for the Advancement of Science), 1999-05, Vol.284 (5418), p.1362-1365
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1999
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7α-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid-binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.284.5418.1362Titel-ID: cdi_proquest_miscellaneous_743662961
- Format
- –
- Schlagworte
- Acids, Animals, Bile, Bile acids, Bile Acids and Salts - biosynthesis, Bile Acids and Salts - metabolism, Biological and medical sciences, Biological Transport, Carrier Proteins - genetics, Carrier Proteins - metabolism, Cell Line, Cell receptors, Cell structures and functions, Chenodeoxycholic Acid - metabolism, Cholesterol, Cholesterol - metabolism, Cholesterol 7-alpha-Hydroxylase - genetics, Cholesterols, Cholic acids, DNA-Binding Proteins - chemistry, DNA-Binding Proteins - genetics, DNA-Binding Proteins - metabolism, Enzymes, Feedback (Response), Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Genes, Hep G2 cells, Histone Acetyltransferases, Homeostasis, Humans, Hydroxysteroid Dehydrogenases, Ligands, Lipids, Literary Devices, Liver, Liver - metabolism, Membrane Glycoproteins, Mice, Miscellaneous, Molecular and cellular biology, Nuclear Receptor Coactivator 1, Nuclear receptors, Organic Anion Transporters, Sodium-Dependent, Physiological aspects, Plasmids, Receptors, Receptors, Cytoplasmic and Nuclear - chemistry, Receptors, Cytoplasmic and Nuclear - genetics, Receptors, Cytoplasmic and Nuclear - metabolism, Symporters, Transcription Factors - chemistry, Transcription Factors - genetics, Transcription Factors - metabolism, Transfection, Tumor Cells, Cultured