Details

Autor(en) / Beteiligte

• KewalRamani, Vineet N.
• Coffin, John M.

Titel

Weapons of Mutational Destruction

Ist Teil von

• Science (American Association for the Advancement of Science), 2003-08, Vol.301 (5635), p.923-925

Ort / Verlag

Washington: American Association for the Advancement of Science

Erscheinungsjahr

2003

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• KewalRamani and Coffin comments on the new function for a cellular protein called APOBEC3G that may act by fighting viral infections through drugs that induce a high rate of mutation to block the replication of retroviruses such as HIV. The protein belongs to a family of nucleic acid editing enzymes related to APOBEC1, a cytidine deaminase that edits the apolipoprotein B messenger RNA (mRNA). Remarkably, APOBEC3G can be incorporated into the virions of unrelated retroviruses, including murine leukemia virus, and its antiviral effect can be counteracted by the Vif of HIV-1.