Science (American Association for the Advancement of Science), 2005-05, Vol.308 (5725), p.1149-1154
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Transcriptional Maps of 10 Human Chromosomes at 5-Nucleotide Resolution
- Ist Teil von
- Science (American Association for the Advancement of Science), 2005-05, Vol.308 (5725), p.1149-1154
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2005
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Sites of transcription of polyadenylated and nonpolyadenylated RNAs for 10 human chromosomes were mapped at 5-base pair resolution in eight cell lines. Unannotated, nonpolyadenylated transcripts comprise the major proportion of the transcriptional output of the human genome. Of all transcribed sequences, 19.4, 43.7, and 36.9% were observed to be polyadenylated, nonpolyadenylated, and bimorphic, respectively. Half of all transcribed sequences are found only in the nucleus and for the most part are unannotated. Overall, the transcribed portions of the human genome are predominantly composed of interlaced networks of both poly A+ and poly A- annotated transcripts and unannotated transcripts of unknown function. This organization has important implications for interpreting genotype-phenotype associations, regulation of gene expression, and the definition of a gene.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1108625Titel-ID: cdi_proquest_miscellaneous_743536190
- Format
- –
- Schlagworte
- Biological and medical sciences, Cell Line, Cell Line, Tumor, Cell lines, Cell Nucleus - metabolism, Chromosomes, Chromosomes, Human - genetics, Chromosomes, Human, Pair 13 - genetics, Chromosomes, Human, Pair 14 - genetics, Chromosomes, Human, Pair 19 - genetics, Chromosomes, Human, Pair 20 - genetics, Chromosomes, Human, Pair 21 - genetics, Chromosomes, Human, Pair 22 - genetics, Chromosomes, Human, Pair 6 - genetics, Chromosomes, Human, Pair 7 - genetics, Chromosomes, Human, X - genetics, Chromosomes, Human, Y - genetics, Coding, Computational Biology, Cytosol, Cytosol - metabolism, DNA, Complementary, DNA, Intergenic, Exons, Female, Fundamental and applied biological sciences. Psychology, Genes, Genetic aspects, Genetics, Genome, Human, Genomes, Genomics, Human chromosomes, Humans, Introns, Male, Molecular and cellular biology, Molecular genetics, Molecular Sequence Data, Nucleic Acid Amplification Techniques, Nucleotides, Oligonucleotide Array Sequence Analysis, Physical Chromosome Mapping, Research Article, Ribonucleic acid, RNA, RNA Splicing, RNA, Messenger - analysis, Transcription, Genetic, Transcription. Transcription factor. Splicing. Rna processing, Transcripts (Written Records)