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The Trichoplax genome and the nature of placozoans
Ist Teil von
Nature, 2008-08, Vol.454 (7207), p.955-960
Ort / Verlag
London: Nature Publishing Group
Erscheinungsjahr
2008
Quelle
PBSC : Psychology and Behavioral Sciences Collection - Journals
Beschreibungen/Notizen
As arguably the simplest free-living animals, placozoans may represent a primitive metazoan form, yet their biology is poorly understood. Here we report the sequencing and analysis of the approximately 98 million base pair nuclear genome of the placozoan Trichoplax adhaerens. Whole-genome phylogenetic analysis suggests that placozoans belong to a 'eumetazoan' clade that includes cnidarians and bilaterians, with sponges as the earliest diverging animals. The compact genome shows conserved gene content, gene structure and synteny in relation to the human and other complex eumetazoan genomes. Despite the apparent cellular and organismal simplicity of Trichoplax, its genome encodes a rich array of transcription factor and signalling pathway genes that are typically associated with diverse cell types and developmental processes in eumetazoans, motivating further searches for cryptic cellular complexity and/or as yet unobserved life history stages.